HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells
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منابع مشابه
HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells
To date, the major role of HPV16E6 in cancer has been considered to be its ability to inhibit the p53 tumor-suppressor protein, thereby thwarting p53-mediated cytotoxic responses to cellular stress signals. Here, we show that HPV16E6-dependent c-fos oncogenic protein expression contributes to AP-1 complex formation under oxidative stress in SiHa cells (HPV16-positive squamous cell carcinoma of ...
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Our previous studies demonstrated retinoic acid (RA) inhibition of activation protein-1 (AP-1) formation in TNF-a-treated osteoblastic MC3T3-E1 cells via c-fos suppression. In the present study, we observed that 1ƒ¿25(OH)2D3 was able to interfere at the transcriptional level with RA inhibition of TNF-a-induced c-fos gene expression in cells when the cells were incubated with the vitamin for 24 ...
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BACKGROUND Activator protein-1 (AP-1) is a mediator of BMP or FGF signaling during Xenopus embryogenesis. However, specific role of AP-1 in activin signaling has not been elucidated during vertebrate development. METHODOLOGY/PRINCIPAL FINDINGS We provide new evidence showing that overexpression of heterodimeric AP-1 comprised of c-jun and c-fos (AP-1(c-Jun/c-Fos)) induces the expression of BM...
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Osteoporosis is a reduction in skeletal mass due to an imbalance between bone resorption and bone formation. Bone morphogenetic protein (BMP) plays important roles in osteoblastic differentiation and bone formation. Therefore, components involved in BMP activation are good targets for the development of anti-osteoporosis drugs. In this study, naringin a polymethoxylated flavonoid, was shown to ...
متن کاملInsulin-stimulated expression of c-fos, fra1 and c-jun accompanies the activation of the activator protein-1 (AP-1) transcriptional complex.
The activator protein-1 (AP-1) transcriptional complex is made up of members of the Fos (c-Fos, FosB, Fra1, Fra2) and Jun (c-Jun, JunB, JunD) families and is stimulated by insulin in several cell types. The mechanism by which insulin activates this complex is not well understood but it is dependent on the activation of the Erk1 and Erk2 isoforms of mitogen-activated protein kinases. In the curr...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 2011
ISSN: 0962-9351,1466-1861
DOI: 10.1155/2011/263216